When I'm trying to reconcile, everything is accounted for with payments and deposits in statements but it's still showing I have a large difference

Welcome to the Community, jdharmon. A significant discrepancy in QuickBooks usually indicates a broken reconciliation history. This happens when a transaction in a previously reconciled period is added, edited, or deleted, causing QuickBooks’ beginning balance to mismatch your bank statement. Other causes include duplicate entries or manual changes to the opening balance.

To fix it, follow these steps:

To review the opening balance in QuickBooks, go to All apps  > Accounting > Chart of accounts. Find the account on the list then select View Register. Search for the opening balance entry. It should have the opening balance equity in the Account column.

However, if you see a duplicate transaction in your bank feed, you can exclude it from the review tab or delete it if it has already been categorized.

To find deleted or edited transactions in QuickBooks, navigate to the Gear icon > Tools > Audit Log. Filter by Deleted/Voided transactions to view who made changes and when.

Don’t hesitate to reply to this post if you have more questions or need additional help.