I've tried to check our records here and found that there's no reported similar to your concern. Can you share if you encounter an error message? This way, I can share with you an accurate solution with this.
Let's figure out if the browser issue is the cause of why you're unable to run payroll.
First, let's try clicking the Reload icon to refresh your browser. If the same thing happens, you can log in using an incognito window. This way, we'll know if it's your regular browser, which causes this unexpected behavior.
If you haven't tried it, you can follow the shortcut keys, depending on what browser you're using.