Thank you for alerting this connectivity issue between QBO with Amex Credit Card to us. Currently, we haven't seen any reports the same as what you're experiencing right now.
In your case, I suggest checking the Banking page if there's an error message so you can send it to us. This way, I can provide you with proper steps to resolve banking errors in QuickBooks Online.
In the meantime, if you have attempted to reconnect your Amex credit card, I suggest disconnecting and reconnecting the account instead. In this manner, you can reauthorise an expired connection.
Before disconnecting and reconnecting your Amex credit card account, ensure no transactions are sitting in the For Review tab. We advise you to match or add them first. Here's how to disconnect your credit card account:
Go to Bookkeeping, select Transactions, then select Banktransactions.
Select the bank account you need to disconnect.
Select the pencil icon✎, then choose Edit account info.